PCL Research & Manufacturing provides contract development and non-GMP manufacturing services that bridge the gap between R&D and supply. We optimise synthesis and crystallization processes from grams to kilograms — ensuring flexible, robust procedures that transfer cleanly to pilot-scale, with consistent and optimised bulk properties.
We can optimise synthesis and crystallization processes, ranging from synthetic route scouting to process scale-up, allowing for batches of grams to kilograms of small-scale non-GMP production — while ensuring flexible and robust procedures that can easily be transferred to pilot-scale and finally to high-volume industrial production of APIs that exhibit consistent and optimised physical and bulk properties.
Our controlled reactor platforms enable precise, reproducible crystallization and synthesis across development scales — providing the control needed to develop and refine robust processes.
Process Analytical Technology (PAT) sensors give real-time insight into crystallization behaviour — particle size, chemistry, supersaturation and thermal events — enabling data-driven process design and tighter control.
Complete downstream isolation capabilities to deliver dry, characterized solids ready for the next development stage — including spray drying for amorphous dispersions and engineered particles.
Our team of expert chemists and analysts is ready to support your drug development — from early-phase screening to non-GMP development and manufacturing.